Early life epigenetic markers as prognostic tools for prediction of adult disease phenotypes
The premise of this project is that environmental cues, such as maternal nutrition, influence the developmental trajectory of the embryo; that the changes in the trajectory are expressed through epigenetic marks that govern gene expression, and that these underpin disease risk in later life. Our work focuses on providing models for and interpreting the results of clinical studies performed in collaboration with colleagues in Singapore, Southampton and Jamaica.
Godfrey KM, Sheppard A, Gluckman PD, Lillycrop KA, Burdge GC, McLean C, Rodford J, Slater-Jefferies JL, Garratt E, Crozier SR, Emerald BS, Gale CR, Inskip HM, Cooper C, Hanson MA (2011) Epigenetic Gene Promoter Methylation at Birth Is Associated With Child’s Later Adiposity. Diabetes: doi: 10.2337/db10-0979