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Integrated life history responses to developmental cues.

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Nutritional and metabolic adaptation: key points

  • The bulk of human evolution occurred in a very different nutritional milieu and the human genotype was selected to be well adapted to that milieu.
  • There is a rising incidence of obesity and its associated disorders in both the developed and developing worlds.
  • There has been a rapid change in diet and behaviour against the background of a genotype that cannot change rapidly.
  • Developmental processes may also contribute to the rising incidence of metabolic mismatch.

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